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Upstream product

• 930-68-7 cyclohexenone 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Microwave assisted Michael addition of cycloalkenones and substituted enones on the surface of alumina in dry media

The Michael addition of ethyl acetoacetate, acetyl acetone and ethyl cyanoacetate to cycloalkenones and β-substituted enones and enal has been accomplished efficiently on the surface of alumina under microwave irradiation in dry media.

Mapping the Surface Groups of Amine-Rich Carbon Dots Enables Covalent Catalysis in Aqueous Media

Carbon nanodots stand as the missing link between the molecular and the nanoscale world, owing to the unique molecular-like behavior emerging from their synthetic precursors. A converging set of analytical and spectroscopic data yields a precise inventory

Amberlyst-15 catalyzed Michael addition of β-dicarbonyl compounds to the enones and unexpected ring closure products

Conjugate addition reactions of 2,4-pentandione, dibenzoylmethane and ethylacetoacetate to enones have been investigated using Amberlyst-15 or Amberlyst-15-DMAP acetate system as catalysts. When 2,4-pentandione reactions were carried out in the presence o

Potassium phosphate-ionic liquid mediated selective mono-Michael addition

A simple and efficient process for an exclusive mono-Michael addition of active methylene compounds to conjugated esters, nitriles and ketones is developed. An ionic liquid-mediated reaction is carried out at room temperature. A reaction carried out at 60 °C resulted in a double-addition product. A mechanism is proposed and supported by P31 and DOSY NMR analysis of the used ionic liquid.

Synthesis of biphenyl-based ligand: Application in copper-mediated chemoselective michael reaction

A biphenyl-based ligand attached was synthesized and screened in copper-mediated Michael reaction. The catalyst system works well with carbon or sulfur nucleophiles as Michael donors and cyclohexenone or chalcones as the acceptors under mild and neutral r

Efficient organocatalytic michael addition reaction of βketoesters under high pressure1

The Michael addition reaction of ketoesters was efficiently promoted by a cooperative dual catalyst system composed by DMAP and thiourea A under high-pressure conditions (0.8 GPa) in toluene. The expected relatively congested adducts of 1,5-dicarbonyl com

Solvent-free Michael addition of 2-cyclohexenone under ultrasonic irradiation in the presence of long chain dicationic ammonium salts

Long chain dicationic ammonium salts (1a-1c), easily prepared from tert-amines and dihaloalkanes, were successfully used as efficient phase-transfer catalysts in the Michael addition reaction of various active methylene compounds to 2-cyclohexenone withou

Efficient microwave activation of hydrotalcite clays in Michael addition under solvent-free conditions

Microwave irradiation has been successfully utilized for the first time for the activation of unmodified hydrotalcites (HTs, a basic anionic clay), in the Michael addition reaction between enones and active methylenic compounds under solventless condition

Ionic liquid as catalyst and solvent: the remarkable effect of a basic ionic liquid, [bmIm]OH on Michael addition and alkylation of active methylene compounds

A basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmIm]OH, catalyzes the Michael addition of active methylene compounds to conjugated ketones, carboxylic esters and nitriles. It further catalyzes the addition of thiols to α,β-acetylenic ketones and alkylation of 1,3-dicarbonyl and -dicyano compounds. The Michael addition to α,β-unsaturated ketones proceeds in the usual way, giving the monoaddition products, whereas addition to α,β-unsaturated esters and nitriles leads exclusively to the bis-addition products. The α,β-acetylenic ketones undergo double conjugate addition with thiols producing β-keto 1,3-dithio-derivatives. In the alkylation reaction the acyclic 1,3-diketones are monoalkylated, whereas cyclic ketones undergo dialkylation under identical conditions. All these reactions were carried out without any organic solvent. The ionic liquid can also be recycled.

α-amino acid induced rate acceleration in aqueous biphasic Lewis acid catalyzed Michael addition reactions

It's as easy as ABC: α-Amino acids may become very important tools in the development of economical and environmentally friendly aqueous biphasic catalysis. Alanine accelerated an Yb(OTf)3-catalyzed Michael addition by a factor of 138. The solubilizing and stabilizing properties of alanine allowed the metal catalyst to be "heterogenized" in the aqueous phase and recycled multiple times without appreciable loss of activity.