944128-18-1

Basic information

• Product Name: (-)-(6S,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-propylpiperidin-2-one
• Synonyms: (-)-(6S,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-propylpiperidin-2-one
• CAS NO: 944128-18-1
• Molecular Weight: 254.373
• Mol File: 944128-18-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(6S,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-propylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(6S,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-propylpiperidin-2-one(944128-18-1)
• EPA Substance Registry System: (-)-(6S,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-propylpiperidin-2-one(944128-18-1)

Safety Data

• Hazardous Substances Data: 944128-18-1(Hazardous Substances Data)

Upstream product

• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 

Downstream Products

• 555-92-0 (S)-coniine hydrochloride 

Relevant articles and documents

Asymmetric synthesis of 6-alkyl- And 6-arylpiperidin-2-ones. Enantioselective synthesis of (S)-(+)-coniine

A variety of diolefinic hydrazides (1) have been assembled in a highly diastereoselective manner by addition of allyllithium to chiral SAMP hydrazones followed by N-acylation with acryloyl chloride. Substrates 1 undergo ring-closing metathesis to give the cyclic enehydrazides (5) which can be easily converted into virtually enantlopure 6-alkyl- or 6-arylpiperidin-2-ones (7). The versatility of this hydrazone addition-RCM protocol has been further exemplified by the conversion of the unsaturated heterocycle 5b into the piperidine alkaloid (S)-(+)-coniine.