944138-03-8

Basic information

• Product Name: 2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
• Synonyms: (2S,3S,4S,5S)-5-(2-acetamido-6-oxo-1H-purin-9(6H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite;2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite;5'-DMT-2'-O-TBDMS-N2-Acetyl-Guanosine Phosphoramidite;5'-DMT-2'-TBDMS-rG(N-Ac) Phosphoramidite;N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• CAS NO: 944138-03-8
• Molecular Formula: C₄₈H₆₄N₇O₉PSi
• Molecular Weight: 942.12
• Mol File: 944138-03-8.mol

Chemical Properties

• Appearance: /
• PKA: 8.93±0.20(Predicted)
• CAS DataBase Reference: 2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(944138-03-8)
• EPA Substance Registry System: 2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(944138-03-8)

Safety Data

• Hazardous Substances Data: 944138-03-8(Hazardous Substances Data)

Usage

Uses

Used in the Synthesis of Modified Nucleotides:
2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used as a key intermediate in the synthesis of C4''-fluorouridine phosphoramidite monomer. This monomer is essential for the preparation of C4''-fluorouridine-modified RNA, which exhibits unique properties and potential applications in various fields.
Used in RNA Therapeutics:
In the RNA therapeutics industry, 2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used as a building block for the development of modified RNA molecules. These modified RNAs can be employed as therapeutic agents, targeting specific genetic disorders or diseases by modulating gene expression or interfering with disease-causing RNA molecules.
Used in RNA Diagnostics:
2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite also finds application in the diagnostics industry, where it can be used to create modified RNA probes for detecting specific RNA sequences or monitoring RNA expression levels. These probes can be integrated into various diagnostic platforms, such as microarrays or qPCR, to improve the sensitivity and specificity of RNA detection.
Used in Research and Development:
In the research and development sector, 2'-O-[(tert-butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite serves as a valuable tool for studying the structure, function, and interactions of RNA molecules. It can be used to create modified RNA constructs for investigating the effects of specific modifications on RNA stability, folding, and binding properties, as well as for exploring the mechanisms of RNA-protein or RNA-RNA interactions.