94419-25-7

Usage

General Description

1-methyl-3-[(2R)-1-methylpyrrolidin-2-yl]pyridinium, also known as N-methyl-4-(2-pyrrolidin-1-yl-2-pyridyl)-pyridine, is a chemical compound with the molecular formula C13H18N2. It is a quaternary ammonium compound that is commonly used as a ligand in coordination chemistry. It is also used as a reactant in organic synthesis, particularly in the formation of heterocyclic compounds. 1-methyl-3-[(2R)-1-methylpyrrolidin-2-yl]pyridinium has been studied for its potential use in pharmaceutical applications, including as an antimalarial agent and in the treatment of neurological disorders. Additionally, it has been investigated for its potential role in catalyzing certain chemical reactions.

Upstream product

• 14031-35-7 S-Adenosyl-L-methionine 
• 25162-00-9 D-nicotine 
• 74-83-9 methyl bromide 
• 54-11-5 nicotin 

Downstream Products

• 89932-51-4 nicotine 

Relevant academic research and scientific papers

The ability of amine N-methyltransferase from rabbit liver to N-methylate azaheterocycles

The substrate specificity of two homogeneous amine N-methyltransferase from rabbit liver has been demonstrated to extent to the azaheterocytes pyridine, R-(+)-nicotine and S-(-)-nicotine. Both enzymes methylate R-(+)-nicotine at the pyridyl nitrogen to afford the N-methylnicotinium salt, whereas S-(-)-nicotine does not act as a substrate for either enzyme. Surprisingly, R-(+)-nicotine is methylated at either the pyridyl nitrogen, or the pyrrolidine nitrogen, to afford the two isomeric monomethylate nicotinium ions when an enzymic preparation containing both methyl transferase activities was used. Under similar conditions S-(-)-nicotine was methylated only at the pyridyl nitrogen. The production of charged metabolites in-vivo, from the large number of pyridino-compounds that are used as drugs, or are present in the environment, may be of toxicological significance, in view of the reported toxicities of several such quaternary ammonium compounds.