94427-54-0 Usage
Uses
Used in Pharmaceutical Development:
(6R,7R)-6-(4-amino-5-bromo-2-oxopyrimidin-1(2H)-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-oxide is utilized as a precursor in the development of novel therapeutic agents aimed at treating viral infections and cancer. Its unique structure allows it to potentially interfere with viral replication and cancer cell proliferation, offering a new avenue for medicinal chemistry.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (6R,7R)-6-(4-amino-5-bromo-2-oxopyrimidin-1(2H)-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide serves as a valuable tool for studying the interactions of nucleic acids with antiviral and anticancer drugs. Its structural features provide insights into the design of more effective and safer pharmaceuticals.
Used in Antiviral Applications:
(6R,7R)-6-(4-amino-5-bromo-2-oxopyrimidin-1(2H)-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-oxide is used as an antiviral agent for its potential to inhibit viral replication processes, offering a new approach to combat viral diseases.
Used in Anticancer Applications:
(6R,7R)-6-(4-amino-5-bromo-2-oxopyrimidin-1(2H)-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide is also used as an anticancer agent, leveraging its ability to interfere with the mechanisms of cancer cell growth and division, thus providing a potential therapeutic strategy against various types of cancer.
Further research and development of (6R,7R)-6-(4-amino-5-bromo-2-oxopyrimidin-1(2H)-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide could lead to the discovery of new pharmaceuticals with improved efficacy and safety profiles, making it a promising candidate for future studies in both academia and the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 94427-54-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,4,2 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 94427-54:
(7*9)+(6*4)+(5*4)+(4*2)+(3*7)+(2*5)+(1*4)=150
150 % 10 = 0
So 94427-54-0 is a valid CAS Registry Number.
94427-54-0Relevant academic research and scientific papers
Beres, Jozsef,Bentrude, Wesley G.,Kruppa, Gabor,McKernan, Patricia A.,Robins, Roland K.
, p. 418 - 422 (1985)
A series of 1-β-ribofuranosyl-5-halocytosine cyclic 3',5'-monophosphates (1-4) has been prepared.Direct halogenation of cytidine 3',5'-monophosphate (cCMP) yielded the Cl,Br, and I compounds while 5-F-cCMP (1) was obtained on cyclization of the 5'-monophosphate.On in vitro testing of 1-4 against L1210 and P388 leukemias, only 1 showed significant low-level activity (ID50=3.1*10-4 mmol/L).Derivatives 2-4 were inactive at 10-1 mmol/L and also proved to have low viral ratings against a series of RNA and DNA virus strains in vitro.By contrast the 5-F-cCMP showed moderate activity against VV, HSV-1, and HSV-2 strains (VR=0.6-0.9).Both 5-fluorocytidine and 5-fluorocytidine-5'-monophosphate had marked antiviral activity (VR=1.0-2.1) with the above viruses as well as with parainfluenza virus type 3.The nucleoside and nucleotide also were more active than 5-F-cCMP against L1210 and P388 cells.However, comparison of the cytoxicities and antiviral ED50 values of 5-F-cCMP, 5-fluorocytidine 5'-monophosphate, and 5-fluorocytidine suggests a potential therapeutic advantage for 5-F-cCMP.Possible rationales for these activities are discussed in terms of 5-F-cCMP and the corresponding 5'-monophosphate as potential prodrugs and as sources, following enzymatic deamination, of cytotoxic 5-fluorouridine or its 5'-monophosphate
