944283-65-2Relevant academic research and scientific papers
"o-Acyl isopeptide method" for peptide synthesis: Synthesis of forty kinds of "o-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH
Yoshiya, Taku,Taniguchi, Atsuhiko,Sohma, Youhei,Fukao, Fukue,Nakamura, Setsuko,Abe, Naoko,Ito, Nui,Skwarczynski, Mariusz,Kimura, Tooru,Hayashi, Yoshio,Kiso, Yoshiaki
, p. 1720 - 1730 (2008/02/10)
The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method. This journal is The Royal Society of Chemistry.
'O-Acyl isopeptide method': racemization-free segment condensation in solid phase peptide synthesis
Yoshiya, Taku,Sohma, Youhei,Kimura, Tooru,Hayashi, Yoshio,Kiso, Yoshiaki
, p. 7905 - 7909 (2007/10/03)
We disclosed a novel 'racemization-free segment condensation' based on the 'O-acyl isopeptide method' in which an N-segment including C-terminal O-acyl isopeptide structure with urethane-protected Ser/Thr residue was employed for the segment condensation,
