944323-25-5

Basic information

• Product Name: C₃₄H₅₇N₅O₁₂
• CAS NO: 944323-25-5
• Molecular Weight: 727.853
• Mol File: 944323-25-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₄H₅₇N₅O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₅₇N₅O₁₂(944323-25-5)
• EPA Substance Registry System: C₃₄H₅₇N₅O₁₂(944323-25-5)

Safety Data

• Hazardous Substances Data: 944323-25-5(Hazardous Substances Data)

Upstream product

• 189687-36-3 diethylenetriaminepentaacetic acid bis(anhydride) 
• 19878-18-3 ethyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride 

Relevant articles and documents

Gd-complexes of DTPA-bis(amide) conjugates of tranexamic acid and its esters with high relaxivity and stability for magnetic resonance imaging

The synthesis and the characterization of a series of DTPA-bis(amide) conjugates of tranexamic acid (L1), its esters (L2-L6), and their Gd(iii) complexes of the type [Gd(L)(H2O)]?nH2O (L = L1-L6) are described. Except for the case of L1, all Gd-complexes exhibit greatly enhanced R1 relaxivity. Highest R1 reaches up to 12.9 mM-1 s-1 for [Gd(L2)(H2O)]. Such high relaxivity is reflected in the intensity enhancement of the in vivo MRI study on H-ras transgenic mice bearing hepatic tumor when employing [Gd(L2)(H 2O)] as an MRI contrast agent. Thermodynamic stability constants, conditional stability constants, and the pM values demonstrate higher stability of [Gd(L)(H2O)]?nH2O (L = L1-L6) than Omniscan under physiological conditions. The MTT assay performed on these complexes reveals cytotoxicity as low as that for Omniscan in the concentration range required to obtain intensity enhancement in the in vivo MRI study. The Royal Society of Chemistry 2008.