944343-01-5Relevant academic research and scientific papers
SUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE AND 5-CARBOXYLIC ESTER KINASE INHIBITORS
-
Page/Page column 19, (2009/05/29)
The present invention is directed to substituted pyrimidine-5-carboxamide and 5-carboxylic ester compounds of Formula (I): and forms thereof wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein and their synthesis and use as kinase inhibitors for treating a chronic or acute protein kinase mediated disease.
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: Design, synthesis, and biological activity
Hughes, Terry V.,Xu, Guozhang,Wetter, Steven K.,Connolly, Peter J.,Emanuel, Stuart L.,Karnachi, Prabha,Pollack, Scott R.,Pandey, Niranjan,Adams, Mary,Moreno-Mazza, Sandra,Middleton, Steven A.,Greenberger, Lee M.
scheme or table, p. 4896 - 4899 (2009/05/07)
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine was synthesized and found to have potent dual EGFR/HER2 kinase inhibitory activity. The structure-based drug design of this molecule as well as the kinase and cellular inhibition of HER2 kinase dependent cell lines will be discussed.
SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS
-
Page/Page column 124, (2008/06/13)
The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
