944344-36-9Relevant academic research and scientific papers
PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)
-
Page/Page column 50; 51, (2015/02/02)
The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar', R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MT
High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice
Boateng, Comfort A.,Bakare, Oluyomi M.,Zhan, Jia,Banala, Ashwini K.,Burzynski, Caitlin,Pommier, Elie,Keck, Thomas M.,Donthamsetti, Prashant,Javitch, Jonathan A.,Rais, Rana,Slusher, Barbara S.,Xi, Zheng-Xiong,Newman, Amy Hauck
, p. 6195 - 6213 (2015/08/24)
The dopamine D3 receptor (D3R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D3R-selective antagonists are effective in animal models of drug abuse, especially
Synthesis and evaluation of fluoro substituted pyridinylcarboxamides and their phenylazo analogues for potential dopamine D3 receptor PET imaging
Nebel, Natascha,Maschauer, Simone,Bartuschat, Amelie L.,Fehler, Stefanie K.,Hübner, Harald,Gmeiner, Peter,Kuwert, Torsten,Heinrich, Markus R.,Prante, Olaf,Hocke, Carsten
, p. 5399 - 5403 (2015/01/08)
A series of fluoro substituted pyridinylcarboxamides and their phenylazo analogues with high affinity and selectivity for the dopamine D3 receptor was synthesized by the use of 6-fluoropyridine-3-carbonyl chloride (1) and fluorophenylazocarboxylic ester (
N -(3-Fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl) arylcarboxamides as selective dopamine D3 receptor ligands: Critical role of the carboxamide linker for d3 receptor selectivity
Banala, Ashwini K.,Levy, Benjamin A.,Khatri, Sameer S.,Furman, Cheryse A.,Roof, Rebecca A.,Mishra, Yogesh,Griffin, Suzy A.,Sibley, David R.,Luedtke, Robert R.,Newman, Amy Hauck
body text, p. 3581 - 3594 (2011/07/29)
N-(3-Fluoro-4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazine-1-yl)butyl) arylcarboxamides were prepared and evaluated for binding and function at dopamine D3 receptors (D3Rs) and dopamine D2 receptors (D2Rs). In this series, we discovered some of the mos
4-PHENYLPIPERAZINE DERIVATIVES WITH FUNCTIONALIZED LINKERS AS DOPAMINE D3 RECEPTOR SELECTIVE LIGANDS AND METHODS OF USE
-
Page/Page column 7, (2010/11/03)
Dopamine D3 receptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylp
4-PHENYLPIPERAZINE DERIVATIVES WITH FUNCTIONALIZED LINKERS AS DOPAMINE D3 RECEPTOR SELECTIVE LIGANDS AND METHODS OF USE
-
Page/Page column 20, (2009/01/24)
Dopamine D3 receptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylp
Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl) arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: Potential substance abuse therapeutic agents
Grundt, Peter,Prevatt, Katherine M.,Cao, Jianjing,Taylor, Michelle,Floresca, Christina Z.,Choi, Ji-Kyung,Jenkins, Bruce G.,Luedtke, Robert R.,Newman, Amy Hauck
, p. 4135 - 4146 (2008/02/11)
Dopamine D3 receptor antagonists and partial agonists have been shown to modulate drug-seeking effects induced by cocaine and other abused substances. Compound 6 [PG01037, (N-(4-(4-(2,3-dichlorophenyl)-piperazin-1-yl)-trans-but-2- enyl)-4-pyridine-2-ylben
