944352-38-9Relevant academic research and scientific papers
An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane β-keto esters
DeGraffenreid, Michael R.,Bennett, Sarah,Caille, Sebastien,De Turiso, Felix Gonzalez-Lopez,Hungate, Randall W.,Julian, Lisa D.,Kaizerman, Jacob A.,McMinn, Dustin L.,Rew, Yosup,Sun, Daqing,Yan, Xuelei,Powers, Jay P.
, p. 7455 - 7458 (2008/02/11)
(Chemical Equation Presented) A simple, scalable, and efficient one-pot methodology for the synthesis of 4,4-disubstituted cyclohexane β-keto esters from benzylic nitriles or esters and methyl acrylate promoted by potassium tert-butoxide is described. The process relies on a tandem double Michael addition-Dieckmann condensation reaction, which results in the formation of three discrete carbon-carbon bonds in a single pot, including a quaternary center. The method allows for the convenient and rapid synthesis of a variety of 4-aryl-4-cyano-2-carbomethoxycyclohexanone and 4-aryl-2,4- biscarbomethoxycyclohexanone building blocks for use in natural products synthesis and medicinal chemistry.
CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
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Page/Page column 189, (2010/11/28)
The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
