944357-02-2Relevant academic research and scientific papers
The asymmetric total synthesis of (+)-cytotrienin A, an ansamycin-type anticancer drug
Hayashi, Yujiro,Shoji, Mitsuru,Ishikawa, Hayato,Yamaguchi, Junichiro,Tamura, Tomohiro,Imai, Hiroki,Nishigaya, Yosuke,Takabe, Kenichi,Kakeya, Hideaki,Osada, Hiroyuki
supporting information; experimental part, p. 6657 - 6660 (2009/03/12)
(Chemical Equation Presented) A star-studded lineup: (+)-Cytotrienin A was the target of an asymmetric total synthesis featuring an enantioselective aldol reaction, α-aminoxylation, deoxygenation, and a ring-closing metathesis to form the 21-membered macrolactam. This first total synthesis confirms the relative and absolute confguration of the molecule.
Carboxylic Acid Compounds and Use Thereof
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Page/Page column 92, (2010/11/28)
Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: [image] wherein each symbol is as defined in the specification.
