944447-16-9Relevant academic research and scientific papers
Novel Chalcone Derivatives With Antimitotic Activity
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Page/Page column 6, (2009/07/25)
The present invention relates to novel chalcone derivatives of formula (I): wherein X, Y, Z, W, RI, R2, R3, R4 and R5 are as defined, said derivatives having antimitotic activity, as well as to pharmaceutical compositions containing such compounds and to their use for making drugs.
Antimitotic and antiproliferative activities of chalcones: Forward structure-activity relationship
Boumendjel, Ahcène,Boccard, Julien,Carrupt, Pierre-Alain,Nicolle, Edwige,Blanc, Madeleine,Geze, Annabelle,Choisnard, Luc,Wouessidjewe, Denis,Matera, Eva-Laure,Dumontet, Charles
, p. 2307 - 2310 (2008/12/22)
A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.
