944470-58-0

Basic information

• Product Name: (S)-tert-butyl 1-(2-chlorophenyl)-3-hydroxypropan-2-ylcarbamate
• Synonyms: (S)-tert-butyl 1-(2-chlorophenyl)-3-hydroxypropan-2-ylcarbamate
• CAS NO: 944470-58-0
• Molecular Weight: 285.771
• Mol File: 944470-58-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 1-(2-chlorophenyl)-3-hydroxypropan-2-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 1-(2-chlorophenyl)-3-hydroxypropan-2-ylcarbamate(944470-58-0)
• EPA Substance Registry System: (S)-tert-butyl 1-(2-chlorophenyl)-3-hydroxypropan-2-ylcarbamate(944470-58-0)

Safety Data

• Hazardous Substances Data: 944470-58-0(Hazardous Substances Data)

Upstream product

• 114873-02-8 N^α-[(tert-butoxy)carbonyl]-2-(chloro)-L-phenylalanine 
• 103616-89-3 (2S)-2-amino-3-(2-chlorophenyl)propanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1026650-78-1 C₁₉H₂₂BrClN₂O₃ 
• 1055968-94-9 methyl 5-{[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-chlorophenyl)propyl]oxy}nicotinate 

Relevant articles and documents

New thiazole carboxamides as potent inhibitors of Akt kinases

A new series of 2-substituted thiazole carboxamides were identified as potent pan inhibitors against all three isoforms of Akt (Akt1, Akt2 and Akt3) by systematic optimization of weak screening hit N-(1-amino-3-phenylpropan-2-yl)- 2-phenylthiazole-5-carboxamide (1). One of the most potent compounds, 5m, inhibited the kinase activities of Akt1, Akt2 and Akt3 with IC50 values of 25, 196 and 24 nM, respectively. The compound also potently inhibited the phosphorylation of downstream MDM2 and GSK3β proteins, and displayed strongly antiproliferative activity in prostate cancer cells. The inhibitors might serve as lead compounds for further development of novel effective anticancer agents.