94453-33-5Relevant academic research and scientific papers
Solid-phase synthesis of substituted alkynes using the Nicholas reaction
Cassel, Johan A.,Leue, Stefanie,Gachkova, Natalie I.,Kann, Nina C.
, p. 9460 - 9463 (2007/10/03)
The first example of a Nicholas reaction on solid phase is reported, involving the reaction of cobalt complexes of polymer-bound alkynols with different nucleophiles in the presence of a Lewis acid, to form carbon-oxygen or carbon-carbon bonds.
An Effective and Selective Conjugate Propargylation Reaction of Stannylallenes to α,β-Unsaturated Carbonyl Compounds and α-Nitro Olefins
Haruta, Jun-ichi,Nishi, Koichi,Matsuda, Satoshi,Akai, Shuji,Tamura, Yasumitsu,Kita, Yasuyuki
, p. 4853 - 4859 (2007/10/02)
Stannylallenes (1) reacted with α,β-unsaturated carbonyl compounds and α-nitro olefins in the presence of TiCl4 to give the corresponding conjugate propargylation products.Thus, the reaction of 1 with cyclic and acyclic α,β-unsaturated carbonyl compounds (2) gave β-propargylic ketones (3) in high yields.With α-nitro olefins (4), two types of products, β-propargylic nitroalkanes (5) and α-propargylic ketones (6), were obtained selectively depending on the presence or absence of the α-substituent of 4.Transformation of the products (6) to cyclopentenone derivatives (10 and 12) are also described.
