944549-41-1Relevant articles and documents
Preparation method of medicine for treating breast cancers
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, (2017/08/28)
The invention provides a preparation method of a medicine for treating breast cancers, in particular to a novel method for preparing N-{3-chloro-4-[(3-fluorobenzyl)methoxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]-4-quinazoline ami
Synthesis of Lapatinib via direct regioselective arylation of furfural
Erickson, Greg,Guo, Jiasheng,McClure, Mike,Mitchell, Mark,Salaun, Marie-Catherine,Whitehead, Andrew
supporting information, p. 6007 - 6010 (2015/01/08)
A new synthesis of Lapatinib, an orally active drug for breast cancer, is described. The synthesis involves a palladium catalyzed regioselective arylation of furfural with 6-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine. This key step replaces an atom inefficient Suzuki cross coupling reaction used in a previously disclosed route and significantly shortens the synthesis.
Quinazoline Derivatives, Preparation Methods and Uses Thereof
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Page/Page column 9, (2009/01/20)
The present invention has disclosed a compound of formula I and a pharmaceutically acceptable salt or a solvate thereof, wherein the substituents are as defined in the description. The invention has also disclosed a method for preparing the compound of formula I, the pharmaceutical compositions comprising the same and their uses in the preparation of an anti-tumor medicament.