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944549-41-1

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  • 6-Bromo-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine

    Cas No: 944549-41-1

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944549-41-1 Usage

General Description

6-Bromo-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine is a chemical compound with potential therapeutic properties. It belongs to the quinazoline family and contains a bromine and a chlorine atom, as well as a fluorophenyl and methoxy group. 6-Bromo-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine has shown promise as a potential anti-cancer agent due to its ability to inhibit certain kinases and disrupt cellular processes involved in tumor growth. Its molecular structure indicates that it may be able to interact with specific proteins and receptors in the body, leading to potential applications in cancer research and drug development. Further studies are needed to fully understand its biological activity and potential medical uses.

Check Digit Verification of cas no

The CAS Registry Mumber 944549-41-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,4,5,4 and 9 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 944549-41:
(8*9)+(7*4)+(6*4)+(5*5)+(4*4)+(3*9)+(2*4)+(1*1)=201
201 % 10 = 1
So 944549-41-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H14BrClFN3O/c22-14-4-6-19-17(9-14)21(26-12-25-19)27-16-5-7-20(18(23)10-16)28-11-13-2-1-3-15(24)8-13/h1-10,12H,11H2,(H,25,26,27)

944549-41-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-bromo-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine

1.2 Other means of identification

Product number -
Other names I14-8831

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:944549-41-1 SDS

944549-41-1Relevant articles and documents

Preparation method of medicine for treating breast cancers

-

, (2017/08/28)

The invention provides a preparation method of a medicine for treating breast cancers, in particular to a novel method for preparing N-{3-chloro-4-[(3-fluorobenzyl)methoxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]-4-quinazoline ami

Synthesis of Lapatinib via direct regioselective arylation of furfural

Erickson, Greg,Guo, Jiasheng,McClure, Mike,Mitchell, Mark,Salaun, Marie-Catherine,Whitehead, Andrew

supporting information, p. 6007 - 6010 (2015/01/08)

A new synthesis of Lapatinib, an orally active drug for breast cancer, is described. The synthesis involves a palladium catalyzed regioselective arylation of furfural with 6-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine. This key step replaces an atom inefficient Suzuki cross coupling reaction used in a previously disclosed route and significantly shortens the synthesis.

Quinazoline Derivatives, Preparation Methods and Uses Thereof

-

Page/Page column 9, (2009/01/20)

The present invention has disclosed a compound of formula I and a pharmaceutically acceptable salt or a solvate thereof, wherein the substituents are as defined in the description. The invention has also disclosed a method for preparing the compound of formula I, the pharmaceutical compositions comprising the same and their uses in the preparation of an anti-tumor medicament.

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