944580-98-7Relevant articles and documents
TRIAZINE COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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Paragraph 0096-0097, (2020/09/17)
The invention discloses a triazine derivative and a pharmaceutically acceptable salt, a pharmaceutical composition and use thereof. Particularly, the invention discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are defined as described in the description and claims. The compound or a salt thereof according to the invention may be used for treating or preventing diseases or conditions by regulating some mutation forms of epidermal growth factor receptors. The invention also discloses a pharmaceutical composition comprising the compound or a salt thereof, and a method for treating various forms of EGFR-mediated diseases (including non-small cell lung cancer) by using the compound and a salt thereof.
Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds
Mu, Bing,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Chang, Junbiao,Wu, Yangjie
supporting information, p. 5260 - 5263 (2016/11/02)
The first Pd-catalyzed tandem cyclization of imidazo[1,2-a]pyridines with 2-chlorobenzaldehydes through C-H arylation and acylation is presented for the efficient synthesis of novel 6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-ones. The direct acylation react