94459-11-7Relevant academic research and scientific papers
N,N-dibenzyloxycarbonylglycyl chloride as useful ketene equivalent in the synthesis of azetidin-2-ones
Cainelli, Gianfranco,Galletti, Paola,Giacomini, Daria
, p. 611 - 612 (2007/10/03)
N,N-3-Dibenzyloxycarbonylaminoazetidin-2-ones have been conveniently prepared from N,N-dibenzyloxycarbonylglycyl chloride and imines or hexahydrotriazines. The β-lactams thus obtained could be monodeprotected by mild hydrogenolysis with Pd on carbon.
A Convenient Synthesis of 4-Unsubstituted β-Lactams
Overman, Larry E.,Osawa, Tatsushi
, p. 1698 - 1701 (2007/10/02)
The reaction of lithium ester enolates with N-(cyanomethyl)amines affords 4-unsubstituted β-lactams in good yields, see eq 1.The N-1 substituent can be varied widely, as can the C-3 substituents, which can be H, alkyl, SPh, NH2, or NHCOR.The preparation o
