94466-83-8Relevant academic research and scientific papers
Lithium diisopropylamide solvated by hexamethylphosphoramide: Substrate-dependent mechanisms for dehydrobrominations
Ma, Yun,Ramirez, Antonio,Singh, Kanwal Jit,Keresztes, Ivan,Collum, David B.
, p. 15399 - 15404 (2006)
Lithium diisopropylamide-mediated dehydrobrominations of exo-2-bromonorbornane, 1-bromocyclooctene, and cis-4-bromo-tert-butylcyclohexane were studied in THF solutions and THF solutions with added hexamethylphosphoramide (HMPA). Rate studies reveal a diverse array of mechanisms based on mono-, di-, and trisolvated monomers as well as triple ions. The results are contrasted with analogous eliminations in THF in the absence of HMPA.
The question of vertical or nonvertical participation of silicon β to a cation in the antiperiplanar stereochemistry
Lambert, Joseph B.,Emblidge, Robert W.,Malany, Siobhan
, p. 1317 - 1320 (2007/10/02)
The mechanism of stabilization of a β positive charge by silicon in the antiperiplanar stereochemistry has been clarified by the β secondary deuterium kinetic isotope effect. A kH /kD of 1.17 ± 0.01 has been observed for the trifluor
