944707-80-6

Basic information

• Product Name: C₂₈H₂₈N₂O₅S
• CAS NO: 944707-80-6
• Molecular Weight: 504.607
• Mol File: 944707-80-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₈N₂O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₈N₂O₅S(944707-80-6)
• EPA Substance Registry System: C₂₈H₂₈N₂O₅S(944707-80-6)

Safety Data

• Hazardous Substances Data: 944707-80-6(Hazardous Substances Data)

Upstream product

• 944707-45-3 C₁₅H₁₄BrNO₂S 
• 1004552-89-9 C₁₃H₁₆BNO₅ 

Relevant articles and documents

Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists

A structurally novel liver X receptor (LXR) agonist (1) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. Compound 1 increased ABCA1 gene expression by eightfold and SREBP1c by threefold in differentiated THP-1 macrophage cell lines. Confirmation of its agonistic activity against LXR was obtained in the co-factor recruitment and reporter transactivation assays. Structure-activity relationship studies on compound 1 are described.