944727-22-4Relevant academic research and scientific papers
Synthesis, structures, and spectroscopic properties of 3-aryl-5-(2-pyridyl) pyrazoles and related pyrazoles
Schowtka, Bjoern,Mueller, Christoph,Goerls, Helmar,Westerhausen, Matthias
supporting information, p. 916 - 925 (2014/04/17)
3-Aryl-5-(2-pyridyl)pyrazoles and related compounds are easily accessible via the reaction of the appropriate 1,3-diketone with hydrazine hydrate. The central pyrazole rings show a far-reaching equalization of the bond lengths. In the crystalline state dimeric and strand-like structures are observed due to the formation of intermolecular N-H...N hydrogen bridges between the pyrazole N-H functionality and a pyrazole or pyridyl base. The structures mainly depend on the steric demand of the aryl groups. Planar 3-aryl-5-(2-pyridyl)pyrazoles also show π stacking reducing the solubility in common organic solvents. Copyright
