944795-40-8Relevant academic research and scientific papers
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics
Bamborough, Paul,Angell, Richard M.,Bhamra, Inder,Brown, David,Bull, James,Christopher, John A.,Cooper, Anthony W.J.,Fazal, Lynsey H.,Giordano, Ilaria,Hind, Lucy,Patel, Vipulkumar K.,Ranshaw, Lisa E.,Sims, Martin J.,Skone, Philip A.,Smith, Kathryn J.,Vickerstaff, Emma,Washington, Melanie
, p. 4363 - 4368 (2007)
2,4-Dianilino pyrimidines are well-known inhibitors of tyrosine kinases including lymphocyte specific kinase (Lck). Structure-activity relationships at the 4-position are discussed and rationalised. Examples bearing a 2-methyl-5-hydroxyaniline substituent
