944795-45-3Relevant academic research and scientific papers
PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS
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Page/Page column 238-239, (2010/11/30)
A compound of formula (I) or a salt or solvate thereof: Formula (1) compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such mono-anilino pyrimidine derivative
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics
Bamborough, Paul,Angell, Richard M.,Bhamra, Inder,Brown, David,Bull, James,Christopher, John A.,Cooper, Anthony W.J.,Fazal, Lynsey H.,Giordano, Ilaria,Hind, Lucy,Patel, Vipulkumar K.,Ranshaw, Lisa E.,Sims, Martin J.,Skone, Philip A.,Smith, Kathryn J.,Vickerstaff, Emma,Washington, Melanie
, p. 4363 - 4368 (2008/02/09)
2,4-Dianilino pyrimidines are well-known inhibitors of tyrosine kinases including lymphocyte specific kinase (Lck). Structure-activity relationships at the 4-position are discussed and rationalised. Examples bearing a 2-methyl-5-hydroxyaniline substituent
