944801-68-7Relevant articles and documents
Ligand-Free and Solvent-Free Synthesis of 1,3-Disubstituted Naphthalenes through Stille Coupling
Mkpenie, Victor,Rohand, Taoufik,Sbi, Sanae,Tanemura, Kiyoshi
, p. 903 - 906 (2020)
A variety of 1,3-disubstituted naphthalenes have been prepared by palladium-catalyzed annulation of (o-ethynylphenyl)acetyl chloride with design of a new synthetic strategy by Stille coupling using functionalized organostannanes. The method affords excellent yields of the substituted naphthalenes and accommodates a wide variety of functional groups under mild conditions. Mechanistic studies show intramolecular cyclization as a major step following C-C bond coupling.