944805-17-8

Basic information

• Product Name: Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester
• Synonyms: Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester;tert-Butyl (4-broMo-5-forMylthiazol-2-yl)carbaMate;2-Methyl-2-propanyl (4-bromo-5-formyl-1,3-thiazol-2-yl)carbamate
• CAS NO: 944805-17-8
• Molecular Formula: C₉H₁₁BrN₂O₃S
• Molecular Weight: 307.16
• Mol File: 944805-17-8.mol

Chemical Properties

• Appearance: /
• Density: 1.625±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.22±0.70(Predicted)
• CAS DataBase Reference: Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester(944805-17-8)
• EPA Substance Registry System: Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester(944805-17-8)

Safety Data

• Hazardous Substances Data: 944805-17-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester is used as a reagent in chemical synthesis and research for its versatile chemical properties and ability to form various compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester is used as a building block for the synthesis of various drugs. Its unique structure allows for the creation of new molecules with potential therapeutic effects.
Used in Agrochemical Industry:
Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester is also utilized in the agrochemical industry for the development of new pesticides and other agricultural chemicals, contributing to more effective and targeted crop protection solutions.
Used in Material Science:
In the field of material science, Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester is employed in the development of new materials and polymers, potentially enhancing their properties and expanding their applications in various industries.
Used in Biological Research:
Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester has been studied for its potential biological activities, such as its role as an anti-fungal or anti-microbial agent, opening up possibilities for its use in medical and environmental applications.
It is crucial to handle and use Carbamic acid, N-(4-bromo-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester with care and in accordance with proper safety procedures due to its chemical nature and potential hazards.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 405939-39-1 tert-butyl 5-bromothiazol-2-ylcarbamate 

Downstream Products

• 1355249-40-9 C₂₂H₂₈N₄O₅S 
• 1355249-46-5 C₂₄H₂₈N₄O₆S 
• 1355249-47-6 C₂₂H₂₈N₄O₅S 
• 1355249-50-1 C₂₃H₃₀N₄O₅S 
• 1355249-54-5 C₃₂H₃₉N₅O₇S 
• 1355249-71-6 C₂₂H₂₄N₄O₄S 
• 1355249-53-4 C₂₃H₂₆N₄O₆S 
• 1355249-70-5 C₂₂H₂₂N₄O₄S 
• 1355249-39-6 C₂₂H₂₆N₄O₅S 
• 1355249-55-6 C₃₀H₃₃N₅O₆S 

Relevant articles and documents

O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS

Described herein are compounds represented by formulas (IA) or (IB) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R1, R3, R4, Y1, Y2, Ar, Z and n are as defined herein.

TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention describes and claims compounds of the Structural Formula (I), Structural Formula (II), or Structural Formula (III). In Formula (I), R1, R2, R3 and R3' are -H or methyl, or R3 and R3' taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -Cl or -Br. In Formula (II), R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-O-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently -H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (O=), which together with the carbon to which they are attached forms a carbonyl group.

TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention describes and claims compounds of the Structural Formula I, Structural Formula II, or Structural Formula III: wherein R1, R2, R3 and R3' are -H or methyl, or R3 and R3 taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -CI or -Br, Formula II wherein R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-0-CR7R8-, wherein R6, R7, and R8 are independently - H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently - H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (0=), which together with the carbon to which they are attached forms a carbonyl group.

Thiazole compounds and methods of use

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.