944807-68-5Relevant academic research and scientific papers
Asymmetric total syntheses of platensimycin
Nicolaou,Edmonds, David J.,Li, Ang,Tria, G. Scott
, p. 3942 - 3945 (2007)
(Chemical Equation Presented) There are two ways about it: One route to the potent antibiotic (-)-platensimycin used a catalytic asymmetric cycloisomerization and the other an auxiliary-controlled asymmetric alkylation to set the configuration at a key chiral center (see scheme, TMS = trimethylsilyl). This latter synthesis also used an oxidative dearomatization step to construct a key spirocyclic intermediate en route to the natural product.
