94482-49-2

Basic information

• Product Name: acetylmethyl ursolic acid
• CAS NO: 94482-49-2
• Molecular Weight: 512.773
• Mol File: 94482-49-2.mol

Chemical Properties

• CAS DataBase Reference: acetylmethyl ursolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: acetylmethyl ursolic acid(94482-49-2)
• EPA Substance Registry System: acetylmethyl ursolic acid(94482-49-2)

Safety Data

• Hazardous Substances Data: 94482-49-2(Hazardous Substances Data)

Upstream product

• 915-32-2 methyl ursolate 
• 108-24-7 acetic anhydride 
• 77-52-1 Ursolic acid 
• 915-79-7 3-acetyloxy-urs-12-en-28-oic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 77-52-1 ursolic acid 

Downstream Products

• 35959-01-4 (1S,2R,4aS,6aS,6bR,10S,12aS,12bR,14bR)-10-Acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid 
• 129215-22-1 (1S,2R,4aS,6aS,6bR,10S,12aS,12bR,14bR)-10-Acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,3,4,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-hexadecahydro-2H-picene-4a-carboxylic acid methyl ester 
• 22425-72-5 (1S,2R,4aS,6aS,6bR,10S,12aS,12bR,14bR)-10-Acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid methyl ester 
• 129199-19-5 C₃₃H₅₀O₆ 
• 129199-20-8 (1S,2R,4aS,6S,6aS,6bR,10S,12aR,12bR,14bR)-10-Acetoxy-6-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid methyl ester 
• 74048-33-2 3β-acetoxy-11α,12α-epoxy-urs-13β,28-olide 

Relevant articles and documents

Hyaluronidase inhibitory activity of pentacylic triterpenoids from prismatomeris tetrandra (Roxb.) K. schum: Isolation, synthesis and QSAR Study

The mammalian hyaluronidase degrades hyaluronic acid by the cleavage of the β-1,4-glycosidic bond furnishing a tetrasaccharide molecule as the main product which is a highly angiogenic and potent inducer of inflammatory cytokines. Ursolic acid 1, isolated from Prismatomeris tetrandra, was identified as having the potential to develop inhibitors of hyaluronidase. A series of ursolic acid analogues were either synthesized via structure modification of ursolic acid 1 or commercially obtained. The evaluation of the inhibitory activity of these compounds on the hyaluronidase enzyme was conducted. Several structural, topological and quantum chemical descriptors for these compounds were calculated using semi empirical quantum chemical methods. A quantitative structure activity relationship study (QSAR) was performed to correlate these descriptors with the hyaluronidase inhibitory activity. The statistical characteristics provided by the best multi linear model (BML) (R2 = 0.9717, R2cv = 0.9506) indicated satisfactory stability and predictive ability of the developed model. The in silico molecular docking study which was used to determine the binding interactions revealed that the ursolic acid analog 22 had a strong affinity towards human hyaluronidase.

CHEMICAL CONSTITUTION OF Ledum palustre

From the herb Ledum palustre L., collected in July in Kostroma province we have isolated β-sitosterol, the triterpenoids taraxerol, uvaol, and ursolic acid, the coumarin fraxetin, the known flavonoids quercetin, hyperoside, and 3,3',7-tri-O-methylquerceti