944898-90-2 Usage
Description
3-Iodo-1H-indazole-5-carbonitrile is a chemical compound with the molecular formula C8H4IN3. It is a derivative of indazole, a heterocyclic aromatic organic compound. The presence of the iodine and carbonitrile functional groups in this compound makes it an important intermediate in the synthesis of pharmaceuticals and agrochemicals. It is commonly used as a building block in the preparation of various biologically active molecules, including potential anti-cancer and antimicrobial agents. Its unique structure and reactivity make it a valuable tool for the development of new drugs and chemicals.
Uses
Used in Pharmaceutical Industry:
3-Iodo-1H-indazole-5-carbonitrile is used as a key intermediate for the synthesis of pharmaceuticals, particularly for the development of potential anti-cancer and antimicrobial agents. Its unique structure and reactivity allow for the creation of biologically active molecules with therapeutic potential.
Used in Agrochemical Industry:
3-Iodo-1H-indazole-5-carbonitrile is also used as a building block in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals that can help improve crop yields and protect against pests and diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 944898-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,4,8,9 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 944898-90:
(8*9)+(7*4)+(6*4)+(5*8)+(4*9)+(3*8)+(2*9)+(1*0)=242
242 % 10 = 2
So 944898-90-2 is a valid CAS Registry Number.
944898-90-2Relevant articles and documents
Suzuki-type cross-coupling reaction of unprotected 3-iodoindazoles with pinacol vinyl boronate: An expeditive C-3 vinylation of indazoles under microwave irradiation
Vera, Gonzalo,Diethelm, Benjamín,Terraza, Claudio A.,Recabarren-Gajardo, Gonzalo
, (2018/09/26)
Herein we report an expeditive C-3 vinylation of unprotected 3-iodoindazoles under microwave irradiation. Ten C-5 substituted 3-vinylindazole derivatives, nine of them novel, were synthesized through this method, which proceeds in moderate to excellent yields starting from C-5 substituted 3-iodoindazole derivatives. In all cases, the C-3 vinylated derivative was the only isolated product. This methodology allows access to 3-vinylated indazoles selectively and directly without the need of N-protection. 3-Vinylindazoles could be interesting synthetic intermediates allowing access to biologically active molecules.
Identification of potent ITK inhibitors through focused compound library design including structural information
Herdemann, Matthias,Heit, Isabelle,Bosch, Frank-Uwe,Quintini, Gianluca,Scheipers, Claudia,Weber, Alexander
scheme or table, p. 6998 - 7003 (2010/12/25)
A series of novel compound libraries inhibiting interleukin-2 inducible T cell kinase (ITK) were designed, synthesized and evaluated. In the first design cycle two library scaffolds were identified showing low micromolar inhibition of ITK. Further iterative design cycles including crystal structure information of ITK and structurally related kinases led to the identification of indolylindazole and indolylpyrazolopyridine compounds with low nanomolar ITK inhibition.
