944898-90-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Iodo-1H-indazole-5-carbonitrile is used as a key intermediate for the synthesis of pharmaceuticals, particularly for the development of potential anti-cancer and antimicrobial agents. Its unique structure and reactivity allow for the creation of biologically active molecules with therapeutic potential.
Used in Agrochemical Industry:
3-Iodo-1H-indazole-5-carbonitrile is also used as a building block in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals that can help improve crop yields and protect against pests and diseases.

Upstream product

• 74626-47-4 1H-indazole-5-carbonitrile 
• 53857-57-1 5-bromo-1H-indazole 

Relevant academic research and scientific papers

Suzuki-type cross-coupling reaction of unprotected 3-iodoindazoles with pinacol vinyl boronate: An expeditive C-3 vinylation of indazoles under microwave irradiation

Herein we report an expeditive C-3 vinylation of unprotected 3-iodoindazoles under microwave irradiation. Ten C-5 substituted 3-vinylindazole derivatives, nine of them novel, were synthesized through this method, which proceeds in moderate to excellent yields starting from C-5 substituted 3-iodoindazole derivatives. In all cases, the C-3 vinylated derivative was the only isolated product. This methodology allows access to 3-vinylated indazoles selectively and directly without the need of N-protection. 3-Vinylindazoles could be interesting synthetic intermediates allowing access to biologically active molecules.

HISTONE DEMETHYLASE INHIBITORS

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine derivative compounds, substituted 3-aminopyridazine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Identification of potent ITK inhibitors through focused compound library design including structural information

A series of novel compound libraries inhibiting interleukin-2 inducible T cell kinase (ITK) were designed, synthesized and evaluated. In the first design cycle two library scaffolds were identified showing low micromolar inhibition of ITK. Further iterative design cycles including crystal structure information of ITK and structurally related kinases led to the identification of indolylindazole and indolylpyrazolopyridine compounds with low nanomolar ITK inhibition.