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4-(4-chlorophenylsulfonyl)-5,8-difluoro-2H-chroMene is a chemical compound with a unique molecular structure consisting of a chroMene ring with substituents including a 4-chlorophenylsulfonyl and two difluoro groups. It is of interest due to its potential applications in medicinal chemistry and materials science.

944950-71-4

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944950-71-4 Usage

Uses

Used in Medicinal Chemistry:
4-(4-chlorophenylsulfonyl)-5,8-difluoro-2H-chroMene is used as a potential candidate for the development of new pharmaceuticals and agrochemicals with targeted activities. Its unique structure and properties make it a promising candidate for research and development in this field.
Used in Materials Science:
4-(4-chlorophenylsulfonyl)-5,8-difluoro-2H-chroMene is used in materials science for its strong fluorescence properties. It has been studied for its potential use in fluorescent labeling and imaging, making it a valuable tool for various applications in this industry.
Research on 4-(4-chlorophenylsulfonyl)-5,8-difluoro-2H-chroMene is ongoing to explore its various potential applications in both medicinal chemistry and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 944950-71-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,4,9,5 and 0 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 944950-71:
(8*9)+(7*4)+(6*4)+(5*9)+(4*5)+(3*0)+(2*7)+(1*1)=204
204 % 10 = 4
So 944950-71-4 is a valid CAS Registry Number.

944950-71-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-chlorophenyl)sulfonyl-5,8-difluoro-2H-chromene

1.2 Other means of identification

Product number -
Other names 4-(4-chloro-benzenesulfonyl)-5,8-difluoro-2H-chromene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:944950-71-4 SDS

944950-71-4Relevant academic research and scientific papers

Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Xu, Ruo,Cole, David,Asberom, Ted,Bara, Tom,Bennett, Chad,Burnett, Duane A.,Clader, John,Domalski, Martin,Greenlee, William,Hyde, Lynn,Josien, Hubert,Li, Hongmei,McBriar, Mark,McKittrick, Brian,McPhail, Andrew T.,Pissarnitski, Dmitri,Qiang, Li,Rajagopalan, Murali,Sasikumar, Thavalakulamgar,Su, Jing,Tang, Haiqun,Wu, Wen-Lian,Zhang, Lili,Zhao, Zhiqiang

scheme or table, p. 2591 - 2596 (2010/07/05)

A novel series of tricyclic γ-secretase inhibitors was designed and synthesized via a conformational analysis of literature compounds. The preliminary results have shown that compounds in this new series have much improved in vitro potency and in vivo pro

TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS

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Page/Page column 229-231, (2009/03/07)

Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in one reaction step using a mixture of an aldehyde (or ketone) and an alkyl substituted with two electron withdrawing groups, and reacting the mixture with: (a) a sulfonyl halide (e.g., a sulfonyl chloride) and a basic tertiary amine, or, (b) a sulfonyl anhydride and a basic amine, or (c) an aryl-C(O)-halide and a basic tertiary amine, or (d) an aryl-C(O)-O-C(O)-aryl and a basic tertiary amine, or (e) an heteroaryl-C(O)-halide and a basic tertiary amine, or (f) a heteroaryl-C(O)-O-C(O)-heteroaryl and a basic tertiary amine.

BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS

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Page/Page column 115; 116-117, (2010/11/28)

This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl

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