945-68-6

Upstream product

• 779-28-2 p-Nitroso-N,N-bis(β-chlorethyl)anilin 
• 553-27-5 aniline mustard 
• 2067-58-5 4-amino-N,N-bis(2-chloroethyl)aniline 
• 100-01-6 4-nitro-aniline 
• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 

Downstream Products

• 64977-04-4 N₁,N₁-bis(2-chloroethyl)-N₄,N₄-dimethylbenzene-1,4-diamine 
• 1492-93-9 N,N-Bis-(2-chlor-aethyl)-4-fluoracetamino-anilin 
• 112352-17-7 4-[bis-(2-chloro-ethyl)-amino]-tri-N-methyl-anilinium; iodide 
• 17614-68-5 N,N-Bis-(2-chlor-ethyl)-4-isothiocyanato-anilin 
• 3042-05-5 benzo[4,5]imidazo[2,1-b]thiazole-2,3-dione 2-({4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hydrazone) 
• 3131-22-4 N-(N-Dichloracetyl-glycyl)-N',N'-bis-(2-chlor-aethyl)-p-phenylendiamin 
• 94461-61-7 N-(N-Formyl-DL-methionyl)-N',N'-bis-(2-chlor-aethyl)-p-phenylendiamin 
• 94824-36-9 N-(N-Acetyl-DL-methionyl)-N',N'-bis-(2-chlor-aethyl)-p-phenylendiamin 
• 95442-73-2 N-Formyl-L-glutaminsaeure-γ-benzylester-α-<4--anilid> 
• 97491-77-5 N-(4--phenyl)-N'-(1-methoxycarbonyl-ethyl)-thioharnstoff 
• 93738-35-3 N-(N-Dichloracetyl-DL-methionyl)-N',N'-bis-(2-chlor-aethyl)-p-phenylendiamin 
• 99998-26-2 N-Formyl-L-tyrosin-(4--anilid) 
• 101227-63-8 N--N',N'-bis-<2-chlor-aethyl>-p-phenylendiamin 
• 1215-17-4 N-(4--phenyl)-harnstoff 

Relevant academic research and scientific papers

A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells

Herein, a novel soluble mitochondria-targeted theranostic compound, HMX-1, was presented, which was selectively activated under hypoxia with excellent mitochondria-targeting ability at the cellular level, accompanied by a dramatic increase in the fluorescence intensity. Moreover, its anti-cancer efficiency was certified both in vitro and in vivo.

HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS

Hypoxia activated drug compounds having a structure of formula(I) are useful in the treatment of cancer and other hyperproliferative diseases.