945000-96-4Relevant academic research and scientific papers
Palladium-Catalyzed Direct C2-Biarylation of Indoles
Murugesan, Tamilarasu,Sivarajan, Chinraj,Jayakumari, Chithra Mohan,Singh, Rajat Kumar,Vennapusa, Sivaranjana Reddy,Kaliyamoorthy, Alagiri
, p. 10838 - 10851 (2021)
Biaryl and indole units are important structural motifs in several bioactive molecules and functional materials. We have accomplished straightforward access to C2-biarylated indole derivatives through palladium-catalyzed C-H activation strategy with a bro
Copper-catalysed selective 3-sulfonylation of indoles: A mild synthesis of indolyl sulfones
Du, Yi,Liu, Yunyun
, p. 579 - 582 (2016/10/18)
The selective C3-sulfonylation of some 4-, 5- and 6-substituted indoles using sodium arenesulfinates as reaction partners has been realised under mild conditions using catalytic CuI/1,10-phenanthroline at 70 °C. The reaction had a satisfactory application
Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles
Heffernan, Gavin D.,Coghlan, Richard D.,Manas, Eric S.,McDevitt, Robert E.,Li, Yanfang,Mahaney, Paige E.,Robichaud, Albert J.,Huselton, Christine,Alfinito, Peter,Bray, Jenifer A.,Cosmi, Scott A.,Johnston, Grace H.,Kenney, Thomas,Koury, Elizabeth,Winneker, Richard C.,Deecher, Darlene C.,Trybulski, Eugene J.
experimental part, p. 7802 - 7815 (2010/03/24)
The discovery of a series of 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles, dual acting norepinephrine reuptake inhibitors (NRIs) and 5-HT2A receptor antagonists, is described. The synthesis and structure-activity relationship (SAR) of this novel
SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS
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Page/Page column 92, (2008/06/13)
The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical comp
