945004-79-5Relevant academic research and scientific papers
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors
Packard, Garrick K.,Papa, Patrick,Riggs, Jennifer R.,Erdman, Paul,Tehrani, Lida,Robinson, Dale,Harris, Roy,Shevlin, Graziella,Perrin-Ninkovic, Sophie,Hilgraf, Robert,McCarrick, Margaret A.,Tran, Tam,Fleming, Yuedi,Bai, April,Richardson, Samantha,Katz, Jason,Tang, Yang,Leisten, Jim,Moghaddam, Mehran,Cathers, Brian,Zhu, Dan,Sakata, Steven
, p. 747 - 752 (2012/03/11)
The serine/threonine specific protein kinase B-Raf is part of the MAPK pathway and is an interesting oncology target. We have identified thieno[2,3-d]pyrimidines as a core scaffold of small molecule B-Raf inhibitors. The SAR of analogs in this series will be described.
