94502-33-7Relevant academic research and scientific papers
Annulation strategies for benzo[b]fluorene synthesis: efficient routes to the kinafluorenone and WS-5995 antibiotics.
Qabaja,Jones
, p. 7187 - 7194 (2000)
Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of tri-O-methylkinafluorenone, providing an effective alternative to Friedel-Crafts-based approaches. During the course of this work, an acid-promoted quinolactonization of naphthoquinones was also developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C, and functional analogues was demonstrated, and antitumoral activity of this class was determined.
Regioselective lactonization of naphthoquinones: Synthesis and antitumoral activity of the WS-5995 antibiotics
Qabaja, Ghassan,M. Perchellet, Elisabeth,Perchellet, Jean-Pierre,Jones, Graham B.
, p. 3007 - 3010 (2007/10/03)
An acid promoted quinolactonization of naphthoquinones has been developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS- 5995A, WS-5995C and functional analogs is demonstrated. Preliminary antitumoral activity of the analogs is presented together with electrochemical analysis. (C) 2000 Elsevier Science Ltd.
