945022-27-5Relevant academic research and scientific papers
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3
Hayes, Martin E.,Breinlinger, Eric C.,Wallace, Grier A.,Grongsaard, Pintipa,Miao, Wenyan,McPherson, Michael J.,Stoffel, Robert H.,Green, David W.,Roth, Gregory P.
, p. 2414 - 2419 (2008/09/20)
Modification of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization.
