945217-60-7 Usage
Uses
Used in Organic Synthesis:
(3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine is used as an intermediate in organic synthesis for the preparation of various complex organic molecules. The Boc protecting group allows for selective reactions to occur at other sites on the molecule, while the 3R,4S stereochemistry ensures the correct spatial arrangement of functional groups.
Used in Pharmaceutical Research:
(3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine is used as a building block in the development of new pharmaceuticals. Its unique stereochemistry and the presence of the Boc protecting group make it a valuable component in the synthesis of bioactive compounds with potential therapeutic applications.
Used in Natural Product Synthesis:
(3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine is used as a key component in the synthesis of natural products that contain pyrrolidine rings. The Boc group facilitates the introduction of additional functional groups, enabling the construction of complex natural product structures with potential biological activities.
Used in Chiral Pool Synthesis:
(3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine is used as a chiral building block in the synthesis of enantioselective compounds. Its defined stereochemistry allows for the controlled introduction of chiral centers in target molecules, which is crucial for the development of enantiomerically pure pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 945217-60-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,2,1 and 7 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 945217-60:
(8*9)+(7*4)+(6*5)+(5*2)+(4*1)+(3*7)+(2*6)+(1*0)=177
177 % 10 = 7
So 945217-60-7 is a valid CAS Registry Number.
945217-60-7Relevant academic research and scientific papers
Discovery of 1-pyrimidinyl-2-aryl-4,6-dihydropyrrolo [3,4-d]imidazole-5(1H)-carboxamide as a novel JNK inhibitor
Cho, Hyunwook,Hah, Jung-Mi,Im, Daseul,Jang, Miyoung,Moon, Hyungwoo,Oh, Youri,Yang, Songyi
, (2020/03/13)
We designed and synthesized 1-pyrimidinyl-2-aryl-4, 6-dihydropyrrolo [3,4-d] imidazole-5(1H)-carboxamide derivatives as selective inhibitors of c-Jun-N-terminal Kinase 3 (JNK3), a target for the treatment of neurodegenerative diseases. Based on the compounds found in previous studies, a novel scaffold was designed to improve pharmacokinetic characters and activity, and compound 18a, (R)-1-(2-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)amino)pyrimidin-4-yl)-2-(3,4-dichlorophenyl)-4,6-dihydro pyrrolo [3,4-d]imidazole-5(1H)-carboxamide, showed the highest IC50 value of 2.69 nM. Kinase profiling results also showed high selectivity for JNK3 among 38 kinases, having mild activity against JNK2, RIPK3, and GSK3β, which also known to involve in neuronal apoptosis.
THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS
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Page/Page column 51, (2010/01/12)
A series of thieno[2,3-6]pyridine derivatives, attached at the 2-position to a substituted anilino moiety, which are substituted in the 3-position by a carbonyl group linked to a pyrrolidin-1-yl ring which in turn forms part of a heteroatom-containing fus
