945324-59-4

Upstream product

• 118-48-9 isatoic anhydride 
• 91-56-5 indole-2,3-dione 
• 62-53-3 aniline 
• 4424-17-3 2-aminobenzanilide 
• 59-48-3 2-oxoindole 

Relevant academic research and scientific papers

An efficient and convenient protocol for the synthesis of novel 1′H-spiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione derivatives

An efficient and direct procedure for the synthesis of novel spiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione derivatives is described. The process employs a condensation reaction of 2-aminobenzamides and isatins in the presence of a catalytic amount o

Β-Cyclodextrin mediated multicomponent synthesis of spiroindole derivatives in aqueous medium

An efficient β-cyclodextrin catalyzed multicomponent synthetic protocol has been developed for the synthesis of spiro[indoline-3,2'quinazoline]-2,4'(3’H)-dione from isatoic anhydride, isatin and primary amine in aqueous medium. This methodology offers a c

2-Aminoethanesulfonic acid: An efficient organocatalyst for green synthesis of spirooxindole dihydroquinazolinones and novel 1,2-(dihydroquinazolin-3(4H)isonicotinamides in water

A facile and efficient one-pot procedure for the preparation of spirooxindole dihydroquinazolinone derivatives and new N-(4-oxo-2-phenyl-1,2-dihydroquinazolin-3(4H)-yl)isonicotinamides from reaction between isatoic anhydride, isoniazid and substituted ald

Iron-Catalyzed Oxidative Coupling of Indoline-2-ones with Aminobenzamides via Dual C-H Functionalization

We describe an unprecedented dual C-H functionalization of indolin-2-one via an oxidative C(sp3)-H/N-H/X-H (X = N, C, S) cross-coupling protocol, which is catalyzed by a simple iron salt under mild and ligand-free conditions and employs air (molecular oxygen) as the terminal oxidant. This method is readily applicable for the construction of tetrasubstituted carbon centers from methylenes and provides a wide variety of spiro N-heterocyclic oxindoles.

V-N-C catalysts anchored to mesoporous Al-SBA-15 with tailorable pore sizes for the synthesis of spirooxindole dihydroquinazolinones derivatives

Heterogeneous nanoscale catalyst was successfully synthesized via anchoring of V-bis(2-aminobenzamide) complex on the Al-SBA-15. This modified mesoporous was identified by several characterization techniques, such as X-ray diffraction, field emission-scanning electron microscopy, Fourier transform-infrared, Brunauer–Emmett–Teller and transmission electron microscopy. V-Bis(2-aminobenzamide)@Al-SBA-15 was found to be an efficient heterogeneous catalyst for the rapid and desirable synthesis of various spirooxindole dihydroquinazolinones derivatives. In addition, the heterogeneous nanocatalyst was chemically stabilized in organic and aqueous solutions as well as can be expeditiously reused for at least seven cycles without a significant loss in catalytic activity.

Aqueous hydrotropic solution: green reaction medium for synthesis of pyridopyrimidine carbonitrile and spiro-oxindole dihydroquinazolinone derivatives

Abstract: From the green chemistry point of view, water is one of the most sustainable solvents for chemical transformations, but there are some limitations to its use as a reaction medium due to the lack of solubility of organic compounds. To overcome this difficulty, we used aqueous hydrotropic solution, which increases the solubility of organic compounds in water by?200-fold. We report an environmentally efficient method for synthesis of pyridopyrimidine carbonitriles and spiro-oxindole dihydroquinazolinones by using 50?% aqueous sodium p-toluene sulfonate (NaPTS) solution at ambient reaction condition. The merits of the present protocol include short reaction time, excellent product yield?with high purity, easy workup procedure and reusability of reaction medium. Graphical abstract: [Figure not available: see fulltext.].

Access to enhanced catalytic core-shell CuO-Pd nanoparticles for the organic transformations

This paper describes the biosynthesis of core-shell CuO-Pd nanoparticles with the aid of a Cyperus rotundus rhizome extract. The crystallinity, surface chemistry, morphology and thermal properties of the synthesized nanoparticles were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, and thermogravimetric analysis. The nanoparticles with Pd covered by a CuO enriched shell showed enhanced catalytic performance for organic transformations to synthesize 2,3-dihydroquinazolin-4(1H)-ones, spirooxindoles, and chromenylpyrimidin-2,4-diones in excellent yield. Moreover, the nanocatalyst can be recycled effectively for five consecutive reactions without significant loss of catalytic activity.

Design, synthesis and docking studies of some spiro-oxindole dihydroquinazolinones as antibacterial agents

Two series of spiro-oxindole dihydroquinazolinone derivatives have been designed and synthesized using a catalytic amount of nano cerium oxide with excellent product yields by a convenient one-pot process. The synthesized compounds were evaluated for thei

An environmental friendly approach for the synthesis of spiro[indoline-3',2-quinazoline]2',4(3H)-dione using 1-methylimidazolium hydrogen sulfate, as reusable catalyst

A facile and environmentally benign procedure for the synthesis of 3-aryl-1H-spiro[indoline-3',2-quinazoline] 2',4(3H)-dione from isatoic anhydride, aromatic amines and isatin derivatives in Bronsted acidic ionic liquid, 1-methylimidazoliumhydrogen sulfate, was reported. The ability to reuse the ionic liquid, the high yield, short reaction time and ease of purification are the important features of this process.

Ethylenediamine diacetate-catalyzed three-component reaction for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their spirooxindole derivatives

Ethylenediamine diacetate (EDDA)-catalyzed one-pot syntheses of biologically interesting 2,3-dihydroquinazolin-4(1H)-ones and their spirooxindole derivatives from isatoic anhydride, amines, and benzaldehydes or isatins via a three-component condensation in aqueous media have been described. This method is of great value because of high yields and ease of handling.