945396-74-7

Upstream product

• 24313-88-0 3,4,5-Trimethoxyaniline 
• 5751-20-2 2-(methylsulfanyl)pyrimidin-4-ol 
• 945396-73-6 2-[(3,4,5-Trimethoxyphenyl)amino]pyrimidin-4(3H)-one 

Downstream Products

• 1335141-05-3 N₄-(3,4-dimethyl-1H-pyrazol-5-yl)-N₄-methyl-N₂-[3,4,5-tris(methyloxy)phenyl]-2,4-pyrimidinediamine 
• 1335140-98-1 N₄-(3,4-dimethyl-1H-pyrazol-5-yl)-N₂-[3,4,5-tris(methyloxy)phenyl]-2,4-pyrimidinediamine 
• 945394-06-9 N~4~-(1H-Indazol-7-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine 

Relevant academic research and scientific papers

INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS

Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same.

PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS

Disclosed are compounds having the formula (I): wherein Z, n, R1, R1A, R3, R4, and R5 are as defined herein, and methods of making and using the same.

PYRIMIDINE DERIVATIVES

The invention concerns benzamide compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, ring A, n, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4, and/or EphA2 and/or Src kinases.

2,4 DI (HETERO) -ARYLAMINO-PYRIMIDINE DERIVATIVES AS ZAP-70 AND/OR SYK INHIBITORS

Disclosed are pyrimidine derivatives of formula (I); wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have ZAP-70 and/or Syk inhibitory activities.