94547-24-7Relevant academic research and scientific papers
3,6-disubstituted pyradazine derivatives
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, (2008/06/13)
A 3,6-disubstituted pyridazine derivative having excellent platelet agglutination inhibitory effects. It is useful for a preventive medicine or a therapeutic medicine for a cerebrovascular disorder such as cerebral thrombosis and cerebral embolism, an ischemic heart disease such as myocardial infarction, and a circulation disorder such as peripheral circulation disorder. A pharmaceutical composition containing a compound of the present invention as an effective ingredient and a process for preparing the same are also disclosed. The compound has the formula (I) STR1 wherein A represents an alkyl group having 3 to 6 carbon atoms; a cycloalkyl group having 5 to 7 carbon atoms; a phenyl group, a thienyl group, a furyl group, a thiazolyl group, a phenoxy group, a phenylalkyl group having 7 to 9 carbon atoms, a phenylthio group, a 5-6 membered saturated heterocyclic group containing one or more nitrogen atoms, a pyridyl group or an imidazolyl group each of which may have at least one substituent selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a halogen atom; B represents (a) --NH--D wherein D represents STR2 (4) --CH3 R4 ; or (5) an alkyl group having 3 to 8 carbon atoms; or STR3 and the ring C represents a benzene ring.
Addition of 3-Thienyllithium to Phthalic Anhydride: A Simple Method for the Synthesis of 9,10-Dihydro-4H-benzocycloheptathiophen-10-one
Majchrzak, Michal W.
, p. 1203 - 1204 (2007/10/02)
Addition of 3-thienyllithium to phthalic anhydride produces a mixture of materials from which 2-(3-thienoyl)benzoic acid was easily separated.Elaboration of the acid side chain and ring closure produced the title compound in good yield.
