945470-01-9

Upstream product

• 858854-82-7 3-chloro-2-iodo-phenol 
• 100-44-7 benzyl chloride 
• 54655-07-1 lithium trimethylsilylacetylenide 
• 138720-02-2 3-benzyloxy-2-iodophenol trifluoromethanesulfonate 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 

Downstream Products

• 945470-10-0 1-benzyloxy-3-chloro-2-phenylethynylbenzene 
• 945470-30-4 4-benzyloxy-2-butyl-1H-indole 
• 945470-24-6 1-benzyl-4-benzyloxy-2-butyl-1H-indole 

Relevant academic research and scientific papers

Catalytic generation of arynes and trapping by nucleophilic addition and iodination

A fair exchange: In the title reaction, alkynyllithium serves as an initiator for benzyne generation through an iodine-lithium exchange (see scheme; Tf=trifluoromethanesulfonyl). When performed in the presence of stoichiometric amounts of a nucleophile, the generated benzyne undergoes attack by lithio nucleophiles to generate aryllithium, which is then iodinated by iodoalkyne to give the iodoarenes 1. Copyright

Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: Application to the preparation of indole inhibitors of phospholipase A 2

(Chemical Equation Presented) An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting materials such as 3-halophenols and 3-chloroanisole. Directed ortho-metalation followed by two pallad