945472-59-3Relevant academic research and scientific papers
Palladium-catalyzed sonogashira-coupling conjoined C-H activation: A regioselective tandem strategy to access indolo- and pyrrolo[1,2- a ]quinolines
Shukla, Satya Prakash,Tiwari, Rakesh K.,Verma, Akhilesh K.
, p. 10382 - 10392 (2013/01/15)
An operationally simple approach for the regioselective tandem synthesis of indolo[1,2-a]quinolines 4a-v and pyrrolo[1,2-a]quinolines 5a-k from 1-(2-bromophenyl)-1H-indole/pyrrole/imidazole 1a-c, 2a,b by the palladium-catalyzed sequential C-C bond formation is described. The developed approach involves the palladium-catalyzed Sonogashira coupling followed by the intramolecular C-C bond formation via C-H activation, which leads to the formation of 6-endo-dig cyclized product. This synthetic methodology accommodates wide functional group variation on alkyne, which proves to be advantageous for the structural and biological activity assessments.
Benzotriazole: an efficient ligand for the copper-catalyzed N-arylation of indoles
Verma, Akhilesh Kumar,Singh, Jaspal,Larock, Richard C.
scheme or table, p. 8434 - 8439 (2009/12/26)
A general, efficient, and inexpensive method for the N-arylation of indoles using a catalytic system derived from CuI and benzotriazole is reported. Selective mono N-arylation of indoles with ortho-dihaloarenes has also been successfully achieved in good yields using this protocol.
Synthesis of indolo[1,2-f]phenanthridines from palladium-catalyzed reactions of arynes
Xie, Chunsong,Zhang, Yuhong,Huang, Zedu,Xu, Peixin
, p. 5431 - 5434 (2008/02/07)
(Chemical Equation Presented) A novel convenient approach for the construction of indolo[1,2-f]phenanthridine was developed from the reaction of arynes with 1-(2-bromophenyl)-1H-indole in the presence of palladium catalyst.
