945483-28-3

Basic information

• Product Name: (3R,αS)-N(1)-tert-butyloxycarbonyl-3-[N'-benzyl-N'-(α-methylbenzyl)amino]pyrrolidine
• Synonyms: (3R,αS)-N(1)-tert-butyloxycarbonyl-3-[N'-benzyl-N'-(α-methylbenzyl)amino]pyrrolidine
• CAS NO: 945483-28-3
• Molecular Weight: 380.53
• Mol File: 945483-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,αS)-N(1)-tert-butyloxycarbonyl-3-[N'-benzyl-N'-(α-methylbenzyl)amino]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,αS)-N(1)-tert-butyloxycarbonyl-3-[N'-benzyl-N'-(α-methylbenzyl)amino]pyrrolidine(945483-28-3)
• EPA Substance Registry System: (3R,αS)-N(1)-tert-butyloxycarbonyl-3-[N'-benzyl-N'-(α-methylbenzyl)amino]pyrrolidine(945483-28-3)

Safety Data

• Hazardous Substances Data: 945483-28-3(Hazardous Substances Data)

Upstream product

• 945483-27-2 (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]pyrrolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 906750-02-5 methyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(N'-benzyl-N'-allylamino)butanoate 
• 906750-03-6 (4R,αS)-N(1)-benzyl-4-[N'-benzyl-N'-(α-methylbenzyl)amino]pyrrolid-2-one 
• 945483-26-1 (4R,αS)-4-[N-benzyl-N-(α-methylbenzyl)amino]pyrrolidin-2-one 
• 17480-69-2 (S)-N-benzyl-1-phenylethylamine 

Downstream Products

• 147081-49-0 (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Asymmetric synthesis of 3,4-anti- and 3,4-syn-substituted aminopyrrolidines via lithium amide conjugate addition

The diastereoselective conjugate addition of homochiral lithium amides to methyl 4-(N-allyl-N-benzylamino)but-2-enoate has been used as the key step in a simple and efficient protocol for the preparation of 3,4-substituted aminopyrrolidines. This protocol provides a complementary and stereoselective route to both anti- and syn-3-amino-4-alkylpyrrolidines as well as anti- and syn-3-hydroxy-4-aminopyrrolidines, in high de and ee via β-amino enolate functionalisation. This methodology has been applied to the synthesis of anti-(3S,4S)- and syn-(3R,4S)-3-methoxy-4-(N-methylamino)pyrrolidine. The Royal Society of Chemistry.