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945493-87-8

GSK 189254 is a selective and potent antagonist of the histamine H3 receptor, a G protein-coupled receptor predominantly found in the central nervous system. It plays a crucial role in the regulation of neurotransmitter release, and its antagonists have been extensively studied for their potential therapeutic applications in various central nervous system disorders.
Used in Pharmaceutical Industry:
GSK 189254 is used as a potential treatment for cognitive deficits associated with conditions such as Alzheimer's disease and schizophrenia. Its antagonistic action on the histamine H3 receptor has shown promising results in preclinical studies, demonstrating improvements in cognitive function and wakefulness in animal models.
Used in Research and Development:
GSK 189254 is used as a research tool to study the role of histamine H3 receptors in the central nervous system and their involvement in neurotransmitter release. This helps researchers to better understand the mechanisms underlying various central nervous system disorders and develop novel therapeutic strategies.
Used in Sleep Disorder Treatment:
GSK 189254 is used as a potential treatment for sleep disorders due to its ability to modulate the histamine H3 receptor, which is involved in the regulation of wakefulness and sleep-wake transitions. By antagonizing this receptor, GSK 189254 may help improve sleep quality and address sleep-related issues in patients.
Used in Obesity Treatment:
GSK 189254 is used as a potential treatment for obesity due to its effects on the central nervous system, particularly in regulating appetite and energy balance. By modulating the histamine H3 receptor, GSK 189254 may help reduce food intake and promote weight loss in obese individuals.

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  • 6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide,hydrochloride

    Cas No: 945493-87-8

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  • 945493-87-8 Structure

  • Basic information

    1. Product Name: GSK 189254
    2. Synonyms: GSK 189254;6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride;6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide:hydrochloride
    3. CAS NO:945493-87-8
    4. Molecular Formula: C21H25N3O2*ClH
    5. Molecular Weight: 387.90304
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 945493-87-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: GSK 189254(CAS DataBase Reference)
    10. NIST Chemistry Reference: GSK 189254(945493-87-8)
    11. EPA Substance Registry System: GSK 189254(945493-87-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 945493-87-8(Hazardous Substances Data)

945493-87-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 945493-87-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,4,9 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 945493-87:
(8*9)+(7*4)+(6*5)+(5*4)+(4*9)+(3*3)+(2*8)+(1*7)=218
218 % 10 = 8
So 945493-87-8 is a valid CAS Registry Number.

945493-87-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide,hydrochloride

1.2 Other means of identification

Product number -
Other names 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methyl-nicotinamide hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:945493-87-8 SDS

945493-87-8Downstream Products

945493-87-8Relevant articles and documents

NOVEL DOSAGE FORM

-

Page/Page column 12, (2008/12/07)

The present invention relates to a novel dosage form, to a process for preparing the dosage form and to the use of the dosage form in the treatment of neurological and psychiatric disorders.

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