Cas 945538-80-7,4-(3-fluorophenyl)-5-hydroxy-5-methyl-1,5-dihydro-2H-pyrrol-2-one

945538-80-7

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Basic information

Product Name: 4-(3-fluorophenyl)-5-hydroxy-5-methyl-1,5-dihydro-2H-pyrrol-2-one
Synonyms: 4-(3-fluorophenyl)-5-hydroxy-5-methyl-1,5-dihydro-2H-pyrrol-2-one
CAS NO:945538-80-7
Molecular Formula:
Molecular Weight: 207.204
EINECS: N/A
Product Categories: N/A
Mol File: 945538-80-7.mol
Article Data: 3

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-(3-fluorophenyl)-5-hydroxy-5-methyl-1,5-dihydro-2H-pyrrol-2-one(CAS DataBase Reference)
NIST Chemistry Reference: 4-(3-fluorophenyl)-5-hydroxy-5-methyl-1,5-dihydro-2H-pyrrol-2-one(945538-80-7)
EPA Substance Registry System: 4-(3-fluorophenyl)-5-hydroxy-5-methyl-1,5-dihydro-2H-pyrrol-2-one(945538-80-7)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 945538-80-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 945538-80-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,5,3 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 945538-80:
(8*9)+(7*4)+(6*5)+(5*5)+(4*3)+(3*8)+(2*8)+(1*0)=207
207 % 10 = 7
So 945538-80-7 is a valid CAS Registry Number.

945538-80-7Upstream product

1737-19-5 (3-fluorophenyl)acetone

945538-80-7Downstream Products

945538-80-7Relevant articles and documents

Thioether-linked dihydropyrrol-2-one analogues as PqsR antagonists against antibiotic resistant Pseudomonas aeruginosa

Sabir, Shekh,Suresh, Dittu,Subramoni, Sujatha,Das, Theerthankar,Bhadbhade, Mohan,Black, David StC.,Rice, Scott A.,Kumar, Naresh

, (2021)

The Pseudomonas quinolone system (pqs) is one of the key quorum sensing systems in antibiotic-resistant P. aeruginosa and is responsible for the production of virulence factors and biofilm formation. Thus, synthetic small molecules that can target the PqsR (MvfR) receptor can be utilized as quorum sensing inhibitors to treat P. aeruginosa infections. In this study, we report the synthesis of novel thioether-linked dihydropyrrol-2-one (DHP) analogues as PqsR antagonists. Compound 7g containing a 2-mercaptopyridyl linkage effectively inhibited the pqs system with an IC50 of 32 μM in P. aeruginosa PAO1. Additionally, these inhibitors significantly reduced bacterial aggregation and biofilm formation without affecting planktonic growth. The molecular docking study suggest that these inhibitors bind with the ligand binding domain of the MvfR as a competitive antagonist.

NOVEL LACTAMS

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Page/Page column 26, (2010/11/28)

The present invention relates to novel lactams of formulae (I) and (II). The present invention further relates to the use of these compounds in the treatment of microbial infections and microbial contamination of surfaces, particularly infections and surf

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