945543-26-0

Basic information

• Product Name: 4-dichloropyridine
• Synonyms: 3-(broMoMethyl)-2;4-dichloropyridine;3-(bromomethyl)-2,4-dichloropyridine
• CAS NO: 945543-26-0
• Molecular Formula: C5H3Cl2N
• Molecular Weight: 147.99002
• Mol File: 945543-26-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-dichloropyridine(945543-26-0)
• EPA Substance Registry System: 4-dichloropyridine(945543-26-0)

Safety Data

• Hazardous Substances Data: 945543-26-0(Hazardous Substances Data)

Upstream product

• 132097-09-7 2,4-dichloro-3-methylpyridine 
• 262423-77-8 2,4-dichloronicotinic acid 
• 607351-40-6 2,4-dichloropyridine-3-carbonyl chloride 
• 945543-24-8 (2,4-dichloropyridin-3-yl)methanol 

Relevant articles and documents

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.