945557-04-0

Basic information

• Product Name: 5-bromo-3-chloropyridine-2-carbonitrile
• Synonyms: 5-bromo-3-chloropyridine-2-carbonitrile;5-Bromo-3-chloro-2-cyanopyridine, 5-Bromo-3-chloropicolinonitrile;5-broMo-2-cyano-3-chloropyridine;5-broMo-3-chloro-2-cyanopyridine;5-broMo-3-chloropicolinonitrile;5-bromo-3-chloro-2-Pyridinecarbonitrile
• CAS NO: 945557-04-0
• Molecular Formula: C₆H₂BrClN₂
• Molecular Weight: 217.453
• Mol File: 945557-04-0.mol

Chemical Properties

• Boiling Point: 289.002 °C at 760 mmHg
• Flash Point: 128.584 °C
• Appearance: /
• Density: 1.854 g/cm³
• Vapor Pressure: 0.00226mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -4.96±0.20(Predicted)
• CAS DataBase Reference: 5-bromo-3-chloropyridine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-chloropyridine-2-carbonitrile(945557-04-0)
• EPA Substance Registry System: 5-bromo-3-chloropyridine-2-carbonitrile(945557-04-0)

Safety Data

• Hazardous Substances Data: 945557-04-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-3-chloropyridine-2-carbonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to undergo various chemical transformations. Its presence in the molecular structure of drugs can contribute to their therapeutic properties, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-bromo-3-chloropyridine-2-carbonitrile is utilized as a precursor in the production of pesticides and other agrochemicals. Its unique structure and reactivity allow for the development of compounds that can effectively control pests and diseases in agriculture.
Used in Organic Synthesis:
5-Bromo-3-chloropyridine-2-carbonitrile is employed as a valuable intermediate in organic synthesis for the preparation of a wide range of chemical products. Its functional groups enable it to participate in numerous reactions, facilitating the creation of diverse organic compounds for various applications.
Safety Considerations:
It is crucial to handle 5-bromo-3-chloropyridine-2-carbonitrile with care due to its potential health and environmental hazards. Proper management and safety measures should be implemented to minimize risks associated with this chemical compound during its production, use, and disposal.

InChI:InChI=1/C6H2BrClN2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H

Upstream product

• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 
• 573675-27-1 3-amino-5-bromopyridine-2-carbonitrile 

Downstream Products

• 1297538-79-4 3-chloro-5-(1-((2-tritylamino)ethyl)-1H-pyrazol-3-yl)picolinonitrile 
• 1256808-29-3 1-(5-bromo-3-chloropyridine-2-yl)ethane-1-on 
• 488713-31-1 5-amino-3-chloro-2-cyanopyridine 

Relevant articles and documents

ANDROGEN RECEPTOR MODULATING COMPOUNDS

Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.

INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS

Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed.