94556-80-6Relevant academic research and scientific papers
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor
Coumar, Mohane Selvaraj,Tsai, Ming-Tsung,Chu, Chang-Ying,Uang, Biing-Jiun,Lin, Wen-Hsing,Chang, Chun-Yu,Chang, Teng-Yuan,Leou, Jiun-Shyang,Teng, Chi-Huang,Wu, Jian-Sung,Fang, Ming-Yu,Chen, Chun-Hwa,Hsu, John T.-A.,Wu, Su-Ying,Chao, Yu-Sheng,Hsieh, Hsing-Pang
experimental part, p. 255 - 267 (2010/12/18)
Herein we reveal a simple method for the identification of novel Aurora kinase A inhibitors through substructure searching of an in-house compound library to select compounds for testing. A hydrazone fragment conferring Aurora kinase activity and heterocy
COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN
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Page/Page column 35-36, (2010/02/14)
A new furopyrimidine compound, their pharmaceutically acceptable salt, and a tyrosine kinase activity inhibitor. The furopyrimidine compound is a compound defined by chemical formula 1, 2, 3 or 4, on their precursor, and can exist as a form of free base or in an acid-addition salt. Since the furopyrimidine compound has an effect of inhibiting activity of DDR2 tyrosine kinase, it can be used in treating illnesses caused by the DDR2 tyrosine kinase activity such as hepatocirrhosis, rheumatoid arthritis or cancer.
First Synthesis of 4H-Furo[3,2-f]pyrrolo[1,2-a][1,4]diazepines
Feng, Xiao,Lancelot, Jean-Charles,Prunier, Herve,Rault, Sylvain
, p. 2007 - 2011 (2007/10/03)
The synthetic pathway leading to 4-H-furo[3,2-f]pyrrolo[1,2-a][1,4]diazepines is described in five steps starting from 2-hydroxyketones via 2-amino-3-furonitriles.
Ring Transformation and Reactions of 2-Amino-4,5-dihydrofuran-3,4-dicarbonitriles
Aran, Vincente J.,Perez, Miguel A.,Soto, Jose L.
, p. 2009 - 2011 (2007/10/02)
The 2-amino-4,5-dihydrofuran-3,4-dicarbonitriles (1a-f) were thermally aromatized to the 2-aminofuran-3-carbonitriles (2a-f) which, in turn, underwent photoxidative ring transformation into the 2,5-dihydro-5-hydroxy-2-oxopyrrole-3-carbonitriles (3b-e).Mil
