94557-00-3Relevant academic research and scientific papers
Synthesis of Various New Nitroxide Free Radical Fatty Acids
Hideg, Kalman,Lex, Laszlo
, p. 1431 - 1438 (2007/10/02)
A generally applicable method is presented for the synthesis of various new nitroxide fatty acid isomers in which the fatty acid chains are attached at different positions of the pyrrolidin-1-oxyl ring.These isomers can be obtained by Michael addition of a nitroalkane to an α,β-unsaturated ketone to give a γ-nitro ketone, followed by ring closure with zinc and ammonium chloride to give a 1-pyrroline N-oxide which then reacts with Grignard reagents to give a pyrrolidin-1-oxyl free radical compound, which undergoes phase transfer oxidation of its terminal unsaturated bond.
