945604-79-5Relevant academic research and scientific papers
Asymmetric synthesis of conformationally constrained Fingolimod analogues - Discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist
Zhu, Ran,Snyder, Ashley H.,Kharel, Yugesh,Schaffter, Lisa,Sun, Qin,Kennedy, Perry C.,Lynch, Kevin R.,Macdonald, Timothy L.
, p. 6428 - 6435 (2008/03/30)
Compound 1 (FTY720, Fingolimod) represents a new generation of immunosuppressant that modulates lymphocyte trafficking by interacting with the S1P1 receptor. Compound 1 also provides a template molecule for studying the molecular biology of S1P
METHOD FOR TREATMENT OF NEUROPATHIC PAIN
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Page/Page column 27, (2008/06/13)
Compounds and methods useful for preventing and treating pain,e.g., neuropathic pain, in a subject in need thereof are provided. The compounds can be "SlP modulating" agents that are capable of inducing a detectable change in SlP receptor activity.
