945608-15-1Relevant articles and documents
Synthesis of 3-Halo-7-azaindoles through a 5- endo -dig Electrophilic Cyclization Reaction
Cunningham, Christopher,Kesharwani, Tanay,Naran, Kajal,Philips, Aimee
supporting information, p. 1246 - 1252 (2019/06/08)
Biologically useful 7-azaindoles were synthesized by electrophilic cyclization of 3-alkynyl- N, N -dimethylpyridine-2-amines with molecular iodine. By this simple atom-economical approach under ambient reaction conditions, a library of interesting 3-iodo-7-azaindoles were synthesized in high yields. To synthesize the corresponding 3-bromo- and 3-chloro-7-azaindoles, an environmentally benign copper-mediated cyclization was employed, with inexpensive, nontoxic, and noncorrosive sodium chloride and sodium bromide as the sources of chlorine and bromine, respectively.
BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS
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Paragraph 00488, (2013/06/06)
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R1 and R2 are as defined herein.
A general modular method of azaindole and thienopyrrole synthesis via Pd-catalyzed tandem couplings of gem-dichloroolefins
Fang, Yuan-Qing,Yuen, Josephine,Lautens, Mark
, p. 5152 - 5160 (2008/02/07)
(Chemical Equation Presented) A palladium-catalyzed reaction of gem-dichloroolefins and a boronic acid via a tandem intramolecular C-N and intermolecular Suzuki coupling process gave corresponding substituted azaindoles or thienopyrroles. This method is a