945618-68-8Relevant academic research and scientific papers
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6- aminopyrimidine inhibitors of cyclin-dependent kinase 2
Marchetti, Francesco,Sayle, Kerry L.,Bentley, Johanne,Clegg, William,Curtin, Nicola J.,Endicott, Jane A.,Golding, Bernard T.,Griffin, Roger J.,Haggerty, Karen,Harrington, Ross W.,Mesguiche, Veronique,Newell, David R.,Noble, Martin E. M.,Parsons, Rachel J.,Pratt, David J.,Wang, Lan Z.,Hardcastle, Ian R.
, p. 1577 - 1585 (2008/02/04)
An efficient synthesis of 2-substituted O4-cyclohexylmethyl-5- nitroso-6-aminopyrimidines from 6-amino-2-mercaptopyrimidin-4-ol has been developed and used to prepare a range of derivatives for evaluation as inhibitors of cyclin-dependent kinas
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
Sayle, Kerry L.,Bentley, Johanne,Boyle, F. Thomas,Calvert, A. Hilary,Cheng, Yuzhu,Curtin, Nicola J.,Endicott, Jane A.,Golding, Bernard T.,Hardcastle, Ian R.,Jewsbury, Philip,Mesguiche, Veronique,Newell, David R.,Noble, Martin E. M.,Parsons, Rachel J.,Pratt, David J.,Wang, Lan Z.,Griffin, Roger J.
, p. 3079 - 3082 (2007/10/03)
A series of O4-cyclohexylmethyl-5-nitroso-6-aminopyrimidines bearing 2-arylamino substituents was synthesised and evaluated for CDK1 and CDK2 inhibitory activity. Consistent with analogous studies with O 6-cyclohexylmethylpurines, 2-
