94565-37-4Relevant academic research and scientific papers
Convenient and Scalable Synthesis of 2,3-Dihydroquinazolin-4(1 H)-one Derivatives and Their Anticancer Activities
Rajaka, Lingayya,Penumati, Nageshwar Rao,Nagaiah,Poornachandra,Kumar, C. Ganesh
, p. 1893 - 1901 (2015)
An efficient and mild InBr3-catalyzed approach to synthesize 2,3-dihydroquinazolin-4(1H)-one derivatives (3a-3aa) has been developed. Notably, all the products were isolated by recrystallization and the reaction is accessible on a gram scale. Moreover, the reactions only require 10-60 min. All the synthesized compounds were evaluated for their in vitro anticancer activity against four human cancer cell lines.
